Introduction Genomics
37 important questions on Introduction Genomics
What is Moore's law?
What would happen if genomic DNA sequences were composed of random nucleotides?
What is the chance of detecting an A in a random DNA sequence?
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What is the chance of detecting a 17-mer sequence?
What is more complex to sequence, the natural genome or random DNA sequences?
What is vertical coverage?
What is the horizontal coverage?
What can you detect with metabolomics?
What advantage does transciptomics have over proteomics?
What molecule transcribes DNA into RNA?
How is mRNA splicing done?
How is transcription controlled by proteins?
What is the library preparation?
What molecule causes chain termination in sequencing?
How can ddNTPs be used to detects nucleotides/sequences?
What do primers do in a PCR?
What is strand-specific RNA sequencing?
What can the data analysis after strand-specific RNA seq determine?
How do you make sure only the first strand is copied in strand-specific RNA seq?
What do the 5' and 3' ends of a DNA sequence indicate?
What is the antisense strand?
What does it mean when Ensemble or UCSC says a gene is on the forward strand?
What is Illumina sequencing?
What is used to identify the nucleotides in Illumina sequencing?
How are the nucleotides identified in Illumina sequencing?
What is Bulk RNA barcoding sequencing?
What do they use to tag the individual RNA samples in BRB?
How can demultiplexing errors arise?
What is an example of one step in the library preparation vulnerable to contamination?
How could you check the cross-contamination in the library preparation?
Why is Sanger sequencing the gold standard?
How can primer mismatches affect PCR yield and specificity?
What is lost in strand-specific RNA sequencing if the library is non-stranded?
When would you use the antisense stand in strand specific RNA sequencing?
Would you use BRB sequencing or full RNA sequencing for a N=96 cohort with a cost cap?
How do repeats break assemblies?
How could you solve repeats in assemblies?
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