Tissue Necrosis - Main types: timing and causes - Morphology

4 important questions on Tissue Necrosis - Main types: timing and causes - Morphology

Morphology of coagulative necrosis

Gross: pale tan to gray, sharp demarcation from adjacent normal, solid

Microscopic: architecture is retained with intense cytoplasmic eosinophilia

Morphology of caseous necrosis

Gross: dry or moist, crumbly or granular or laminated, +/- central exudate

Microscopic: architecture lost, lysed cells (including inflammatory cells), granular to amorphous debris, nuclear debris

Morphology of liquefactive necrosis

Gross: pale to transluscent, soft to liquid, cavitations

Microscopic: architecture lost, parenchymal cells lost, space filled with inflammatory cells
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Morphology of dry gangrenous necrosis

Gross: dry, leathery

Microscopic: coagulation necrosis

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