Healing of epithelium
3 important questions on Healing of epithelium
How do tissues heal?
1. Fibrin forms scaffold for cell migration in MINUTES
2. Necrotic tissue is removed by macrophages and neutrophils in DAYS
3. Macrophages and platelets secrete proteins to initiate tissue repair in HOURS
4. New blood vessels and fibroblasts invade the would along fibrin scaffold in 2-3 DAYS
5. Fibroblasts secrete collagen in 4-5 days
6. Remodelling and contraction in WEEKS TO MONTHS
2. Necrotic tissue is removed by macrophages and neutrophils in DAYS
3. Macrophages and platelets secrete proteins to initiate tissue repair in HOURS
4. New blood vessels and fibroblasts invade the would along fibrin scaffold in 2-3 DAYS
5. Fibroblasts secrete collagen in 4-5 days
6. Remodelling and contraction in WEEKS TO MONTHS
How do EPITHELIAL tissues heal?
Events
1. Rapid sliding of survival epithelial cells
2. Delayed proliferation and migration of epithelial cells
3. Differentiation
Requirements
1. Intact connective tissue framework
2. Adequate vascular supply
3. Mitotically active epithelium
1. Rapid sliding of survival epithelial cells
2. Delayed proliferation and migration of epithelial cells
3. Differentiation
Requirements
1. Intact connective tissue framework
2. Adequate vascular supply
3. Mitotically active epithelium
How do EPITHELIAL tissues repair?
Events
1. Repair of the matrix, if needed
2. Rapid sliding of epithelium
3. Delayed proliferation and migration of epithelium
Requirements
1. Intact connective tissue framework
2. Adequate vascular supply
3. Mitotically active epithelium
1. Repair of the matrix, if needed
2. Rapid sliding of epithelium
3. Delayed proliferation and migration of epithelium
Requirements
1. Intact connective tissue framework
2. Adequate vascular supply
3. Mitotically active epithelium
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