Angiogenesis - Inhibition of angiogenesis
3 important questions on Angiogenesis - Inhibition of angiogenesis
How can we block angiogenesis?
We can block VEGF or the signaling cascade generated by VEGF
How can we specifically block VEGF?
Drugs such as Avastin can prevent the binding of VEGF to VEGFR by binding directly to VEGF as a monoclonal antibody
How can we block the signaling cascade generated by VEGF?
Drugs such as Sutent (Sunitinib) can target VEGFRs by binding reversibly to their ATP-binding pockets
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