N=You; neurodevelopmental
7 important questions on N=You; neurodevelopmental
How can you translate behaviour form models?
An E/I balance is needed for balanced information transport.
What is very important to take into consideration in neurodevelopmental disorders?
- Cause
- Associate it in place, time and function. Brain and neurodevelopment
- Temporal relations => is it better or worse
- Think about treatment -> different types => bring personalized medicine to the patient
Same mutation but different phenotype =>
- Importance of time! => development is a temporal effect
- Diet
- Environment
- Physical activity
- Other genetic factors that interfere
Understand the relation between genetics --> behaviour.
What does low vs high E/I balance do?
Much inhibition = developmental delay
Less exhibitory = epilepsy
- Higher grades + faster learning
- Never study anything twice
- 100% sure, 100% understanding
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What are the symptoms of STXBP1?
- Low E/I balance in the beta range (concentration)
- Lower frequency (delta) activity
What are the treatment options for STXBP1 (intellectual disability)? On different levels.
- Gene level: gene therapy => targets the reduced protein levels
- Target the synaptic deficits with small molecules.
- Target circuits
- Target system deficits => increases I/E balance => drug tested = Bumetanide
- Symptoms therapy = diet
What is the rationale behind bumetanide?
Input of chloride
On group level it works.
New case. Boy with developmental problems. What to do?
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
