CNS - Depression & Bipolar - INTRO - Tetracyclines & Atypical Antidepressants

8 important questions on CNS - Depression & Bipolar - INTRO - Tetracyclines & Atypical Antidepressants

What type of antagonist is Nefazodone?

Nefazodone is a selective post synaptic antagonist (5HT2A). It demonstrates moderate serotonin and weaker noradrenaline reuptake inhibition. It has low affinity for muscarinic, ACH, DA, histamine, and α-adrenoreceptors.

What are some examples of atypical antidepressants?

  • Bupropion
  • Mirtazapine
  • Trazodone
  • Vilazodone
  • Vortioxetine
  • Nefazodone

Describe the metabolism and bioavailability of Nefazodone.

Nefazodone undergoes extensive first-pass metabolism with absolute bioavailability of approximately 20%. BID administration is required. It demonstrates moderate serotonin and weaker noradrenaline reuptake inhibition.
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What are mianserin and mirtazepine classified as?

Mianserin and mirtazepine are classified as tetracyclic antidepressants. Mirtazepine is also known as 6-aza-mianserin. They are the first second-generation antidepressants.

What is the mechanism of action (MOA) for atypical antidepressants?

  • 5-HT1A and 5-HT2 antagonists
  • Weak SSRI activity
  • Alpha-1 and H1 antagonism

What is the mechanism of action for the first second-generation antidepressant?

The first second-generation antidepressant is an alpha-2 adrenoceptors antagonist with some affinity for 5-HT1A, 5-HT2A, 5-HT3, alpha-1 adrenoceptors, and H1 receptors.

What is a unique characteristic of Bupropion among atypical antidepressants?

Bupropion is also a weak N and DA reuptake inhibitor.

How is mirtazepine also known in terms of its antidepressant classification?

Mirtazepine is also known as a noradrenaline and specific serotonin antidepressant (NaSSA).

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