CNS - Cholinergics A ntagonists - INTRO - Semi-synthetic & Synthetic Atropine

13 important questions on CNS - Cholinergics A ntagonists - INTRO - Semi-synthetic & Synthetic Atropine

What is the ophthalmic use of topical Atropine?

Topical Atropine is used to facilitate fundus examination in ophthalmic use.

What are antimuscarinics used for in Parkinsonism?

Antiparkinsonian Atropine-like substitutes reduce rigidity, tremors, and autonomic effects of Parkinsonism. Examples include Benzhexol, Benztropine, and Biperiden.

How are antimuscarinic drugs used in cardiovascular treatment?

  • Treatment of Bradycardia and heart block following acute myocardial infarction.
  • Hypertensive carotid sinus to prevent reflex vagal stimulation.
  • Cardio-acceleration: Atropine or Ipratropium used in AV block.
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What are some drugs with atropine-like action used as atropine substitutes?

Drugs with atropine-like action used as atropine substitutes include:
  • Pethidine
  • Anti-histamines
  • Tricyclic antidepressants
  • Antipsychotics

How is Hyoscine used for motion sickness?

Hyoscine (scopolamine) can be given by injection, oral, dermal patch, or transdermally, which is effective for 24-48 hours.

What is the respiratory use of Ipratropium bromide?

Ipratropium bromide (by inhalation) is an effective bronchodilator sparing mucous viscosity used in Asthma.

What are some anti-parkinsonian Atropine substitutes?

  • Benzotropine
  • Benzhexol/Trihexyphenidyl (Artane)
  • Trihexyphenidyl: used for parkinsonism and control of extrapyramidal side effects due to atypical antipsychotic drugs
  • Biperiden

What is the role of antimuscarinics in pre-anaesthetic medication?

Atropine, Hyoscine, and Glycopyrrolate are used to inhibit secretions, dilate bronchi, act as anti-emetics, and prevent reflex vagal stimulation.

How is Scopolamine structurally related to Atropine?

Scopolamine is structurally related to Atropine. It differs from Atropine in several ways:
  • It is chiefly a CNS depressant.
  • It produces amnesia.
  • It is more effective against motion sickness.
  • Its mydriatic effect is briefer than with Atropine.

What is Ipratropium bromide and how is it used?

Ipratropium bromide is a synthetic analogue of Atropine used by inhalation as a bronchodilator. Used in status asthmaticus, an emergency in asthma.

What is the primary use of Hyoscine-butylbromide (Buscopan)?

Hyoscine-butylbromide (Buscopan) is used mainly against smooth muscle spasm and hypermotility, e.g., stomach cramps.

What are the uses of mydriatic and cycloplegic atropine substitutes for ophthalmic use?

They are used to paralyze the ciliary muscles and dilate the pupil. Cyclopentolate (0.5-2%) has short duration. Tropicamide (0.5-1%); short duration (6 hours). It produces mydriasis but inadequate cycloplegia.

Why is Pirenzepine preferred over other antimuscarinic drugs in peptic ulcer treatment?

Pirenzepine is preferred over other antimuscarinic drugs in the treatment of peptic ulcer because it has few side effects due to its selective on M1.

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