Proton pum inhibitors (PUD) - Mucosal Protective Agents - Misoprostol

4 important questions on Proton pum inhibitors (PUD) - Mucosal Protective Agents - Misoprostol

What are some adverse effects of Misoprostol?

  • Severe colic pain of stomach and intestine
  • Diarrhea
  • Severe uterine contractions (Contraindicated in pregnancy)
  • Vaginal bleeding
  • Decreased male and female fertility

What are the pharmacological effects of Misoprostol?

Misoprostol decreases HCl secretion, increases mucous secretion, stimulates tight junctions in GIT mucosa, and increases blood flow to gastric mucosa.

How does Misoprostol affect tight junctions in GIT mucosa?

Misoprostol stimulates tight junctions in GIT mucosa, thereby inhibiting H+ ion back diffusion. This is part of its cytoprotective action.
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What is the use of Misoprostol in PUD?

Misoprostol is used to promote healing of Gastric Ulcer but NOT Duodenal Ulcer in Peptic Ulcer Disease (PUD).

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