GIT - Proton pum inhibitors (PUD) - Mucosal Protective Agents

3 important questions on GIT - Proton pum inhibitors (PUD) - Mucosal Protective Agents

What are some examples of mucosal protective agents (cytoprotectives)?

Examples of mucosal protective agents (cytoprotectives) include:
  • Sucralfate
  • Misoprostol
  • Bismuth
  • Polaprezine
  • Carbenoxolone

What are some adverse effects of Carbenoxolone?

  • Oedema
  • Congestive heart failure
  • Hypertension
  • Hyperkalemia
  • Hyperglycemia

What are the pharmacological effects of Carbenoxolone in promoting the healing of peptic ulcers?

Carbenoxolone promotes healing of peptic ulcers by:
  • Increasing mucous secretion
  • Increasing collagen formation at ulcer base
  • Prolonging gastric epithelial life-span

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