CNS - Depression & Bipolar - INTRO - SNRIs

7 important questions on CNS - Depression & Bipolar - INTRO - SNRIs

What type of inhibitor is Venlafaxine and what neurotransmitter does it weakly inhibit?

Venlafaxine is an SNRI and a weak inhibitor of DA. It inhibits 5HT 5 times more than noradrenaline. It undergoes extensive first-pass metabolism.

What are the different mechanisms of drugs within the class of Serotonin and Noradrenaline Reuptake Inhibitors (SNRIs) compared to TCAs?

Drugs within the class of Serotonin and Noradrenaline Reuptake Inhibitors (SNRIs) have different mechanisms when compared to TCAs. They are similar to SSRIs.

What is available for Venlafaxine that allows once-daily dosing?

A modified-release formulation is available for Venlafaxine, allowing once-daily dosing. Adverse effects include nausea, vomiting, anorexia, headaches, increased sweating, rashes, agitation, and more.
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Which SNRI is a more potent inhibitor of 5-HT than noradrenaline reuptake?

Venlafaxine is a more potent inhibitor of 5-HT than noradrenaline reuptake.

Which SNRI is a more potent inhibitor of noradrenaline than 5-HT reuptake?

Milnacipran is a more potent inhibitor of noradrenaline than 5-HT reuptake.

What percentage of patients reported increased blood pressure as an adverse effect of Venlafaxine?

An increased blood pressure has been reported in 3% of patients taking Venlafaxine. It also causes nausea, vomiting, anorexia, headaches, and more.

What are some other examples of SNRIs besides Venlafaxine and Milnacipran?

Other examples of SNRIs include:
  • Desvenlafaxine
  • Duloxetine
  • Levomilnacipran

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