CNS - Cholinomimetics - direct acting - Indirect acting
12 important questions on CNS - Cholinomimetics - direct acting - Indirect acting
What are the therapeutic uses of Neostigmine?
- Myasthenia gravis
- Urinary retention
- Antidote to NMB's
- Postoperative ileus
- Atonic constipation
- Paroxysmal supraventricular tachycardia
What are some examples of organophosphate compounds used as pesticides?
- Dichlorvos (Doom/Boom)
- Di-isopropylflourophosphate
- Echothiophate
- Malathion
- Parathione
What is the dosage for Neostigmine in treating Myasthenia gravis?
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What do indirectly acting cholinomimetics do to AChE in the cholinergic synapse?
Which organophosphate compound is not highly lipid soluble and cannot cross the blood-brain barrier?
What are the adverse effects of Neostigmine?
- Cardiac arrhythmias
- Muscle fasciculation & paralysis
- Nausea, vomiting, diarrhea
- Salivation, bronchospasm
- Urinary frequency, sweating
What are the therapeutic uses of Physostigmine?
- Glaucoma (0.25-0.5% topical solution)
- Alzheimer’s disease (adjuvant)
- Anti-muscarinic & TCA drug poisoning
What is the dosage for Physostigmine in treating Glaucoma?
What are the adverse effects of Physostigmine?
- Lacrimation, headache
- Allergic follicular conjunctivitis
- Vomiting, diarrhea, salivation
- Bronchospasm
- CNS excitation, convulsions
What is the therapeutic use of Pyridostigmine?
What is the average dosage for Pyridostigmine?
What are the adverse effects of Pyridostigmine?
- Bronchial secretions
- Bronchospasm
- Cardiac arrhythmias
- Muscle weakness
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