CNS - NMB - INTRO - Depolarizing NMB
23 important questions on CNS - NMB - INTRO - Depolarizing NMB
In which patients is succinylcholine contraindicated?
What is hyperkalemia associated with in the context of succinylcholine side effects?
What causes succinylcholine apnoea?
- Low levels of plasma cholinesterase enzyme (e.g., in liver disease or malnutrition).
- Abnormal enzyme (e.g., genetic defect).
- Failure of succinylcholine breakdown leads to apnoea.
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What can contracture and paralysis affect in relation to succinylcholine?
What is the structural classification of Succinylcholine?
What is the treatment for succinylcholine apnoea?
- Support respiration.
- Phase I block: Blood transfusion to supply the enzyme (plasma ACHE).
- Phase II block: Give Neostigmine + Atropine IV.
What are the effects of fasciculations due to succinylcholine?
- Post-operative muscle pain and rhabdomyolysis due to unsynchronized muscle contractions.
- Increased intra-ocular tension.
- Increased intra-abdominal pressure and risk of gastric aspiration.
How is Succinylcholine hydrolyzed?
What causes desensitization of nicotinic receptors to ACh in Phase II block?
What causes succinylcholine to persist for a long period of time in Phase I block?
How do anticholinesterase agents affect Phase II block?
What is the duration and onset of action for Succinylcholine?
What is the onset and duration of action for suxamethonium?
What is the result of the persistence of depolarization in Phase I block?
What is the action of Succinylcholine (Suxamethonium) chloride as a skeletal muscle relaxant?
How does the hydrolysis of suxamethonium compare to ACH?
How do anticholinesterase agents affect Phase I block?
How does Succinylcholine bind at the myoneural junction?
Can the action of suxamethonium be reversed?
What role does Succinylcholine play as an acetylcholine agonist?
When should suxamethonium be given and what are its effects?
What is the effect of Succinylcholine on muscle contractions?
How does premedication with atropine affect suxamethonium use?
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