Proton pum inhibitors (PUD) - Mucosal Protective Agents - Sucralfate

8 important questions on Proton pum inhibitors (PUD) - Mucosal Protective Agents - Sucralfate

How should sucralfate be administered with antacids or H2 blockers?

Sucralfate is active only in gastric acid medium, so if antacids or H2 blockers are given, they should be at least 1 hour apart (after meals).

What are the therapeutic uses of sucralfate?

  • Duodenal Ulcer
  • Gastric Ulcer
  • Gastro-Esophageal Reflux Disease (GERD)

What are some common side effects of sucralfate?

It can cause dry mouth, nausea, vomiting, flatulence, and constipation.
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What is Sucralfate composed of?

Sucralfate is a complex salt of sucrose containing sulfate and poly-aluminium hydroxide.

What is the recommended dose of sucralfate?

Orally 1 g given before meals, QID for 4 weeks.

What adverse effects can sucralfate have in renal diseases?

In renal diseases, sucralfate can cause Aluminium toxicity, Osteomalacia, and Encephalopathy (5% of the drug is absorbed orally).

Describe the mechanism of Sucralfate in an acid medium.

In an acid medium, negatively charged sulfate groups bind to positively charged proteins in the ulcer base, forming a stable protective barrier against acid, bile, and pepsin.

How does sucralfate affect the absorption of co-administered drugs?

Sucralfate binds some co-administered drugs, decreasing their absorption, so administer at least 2 hours apart.

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