Summary: Pharm 1

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Read the summary and the most important questions on Pharm 1

  • 1 Unit 1

  • 1.1 Anticoagulants

  • What triggers collagen release in the mechanism of action of coagulation modifiers?

    Injury or insult to vessel walls triggers collagen release.
  • What is the role of platelets in coagulation?

    Platelets contribute to platelet aggregation.
  • What leads to clot or plug formation?

    Platelet aggregation leads to clot or plug formation.
  • What is the sequence from prothrombin to fibrin?

    Prothrombin is converted to thrombin, which then converts fibrinogen to fibrin.
  • What role does Vitamin K play in coagulation?

    Vitamin K is involved in coagulation activation.
  • What happens after tissue thromboplastin release?

    Tissue thromboplastin release leads to coagulation activation.
  • 1.1.1 Heparins

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  • What are the contraindications for Heparins?

    • Uncontrolled or Active bleeding
    • GI ulcerations
    • Severe hypertension
    • Severe Thrombocytopenia
  • What is the form of Enoxaparin (Lovenox)?

    Form: Sub-Q only
    • Prefilled syringes
  • What is the antidote for Heparins?

    Antidote: Protamine Sulfate
  • What is Heparin Induced Thrombocytopenia (HIT)?

    Heparin Induced Thrombocytopenia (HIT) can develop days after starting heparin. It can lead to serious conditions such as PE, a stroke, or a heart attack. Symptoms include:
    • Skin changes
    • Pain/swelling
    • Breathing difficulties
    • Abdominal pain

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