Lecture title - Parkinsons - COMT Inhibitors

15 important questions on Lecture title - Parkinsons - COMT Inhibitors

What type of inhibitor is mentioned in the document?

COMT Inhibitors/Decarboxylase Inhibitor

What should be given with levodopa-carbidopa according to the COMT Inhibitor nursing implications?

Give with levodopa-carbidopa.

What combination of drugs is referred to in the document?

Levodopa/carbidopa/entacapone (Stalevo)
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What is the black box warning associated with COMT Inhibitors?

BLACK BOX WARNING

What should not be done abruptly according to the COMT Inhibitor nursing implications?

Do not stop abruptly.

What are the most common adverse effects of COMT inhibitors?

  • Disorientation
  • Confusion
  • Hallucinations
  • Psychosis
  • Dry mouth
  • Dizziness
  • Orthostatic Hypotension

What are the contraindications listed for COMT Inhibitors?

  • Disease
  • Nontraumatic Rhabdomyolysis
  • Hyperpyrexia
  • Confusion

What precaution should be taken when driving or operating heavy machinery according to the COMT Inhibitor nursing implications?

Caution when driving or operating heavy machinery.

What does COMT stand for in the context of inhibitors?

Catecholamine O-Methyl Transferase

What is the most severe adverse effect of COMT inhibitors?

Fulminant Liver Failure

What can be used for dry mouth according to the COMT Inhibitor nursing implications?

Hard candy or gum for dry mouth.

Name one COMT inhibitor mentioned in the material.

Tolcapone (Tasmar)

What lab test is recommended according to the COMT Inhibitor nursing implications?

Labs: Liver Function Test.

Name another COMT inhibitor mentioned in the material.

Entacapone (Comtan)

What substances should be avoided according to the COMT Inhibitor nursing implications?

Avoid Alcohol or other CNS depressants.

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