Introduction - Lecture questions

4 important questions on Introduction - Lecture questions

A 100% recovery of unchanged drug in urine indicated that the drug is completely absorbed systemically and not metabolized. False or true, explain.

Correct, it is possible, although uncommon, the drug forms an unstable metabolite, which during storage of the urine sample is converted back to parent drug before the assay is performed. The statment is generally correct.

The maximum amount of drug in the body occurs when the rate of absorption and rate of elimination are equal. False or true, explain.

Correct. At the maximum, the net rate of change of drug in the body is zero. Thereafter, the rate of elimination exceeds that of absorption, so that the amount of drug in the body declines.

A drug is completely recovered (100%) as a glucuronide in the feces. Fecal excretion in therefore the route of elimination of this drug.

Incorrect. The route of elimination of this drug is the formation of the glucuronide. The glucuronide is then secreted into the bile and subsequently excreted into the feces.
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The rate of change of the drug in the body is equal to the rate of absorption at the peak time.

Incorrect. The rate of change of drug in the body is zero at the peak time. Here, the rates of absorption and elimination are equal

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