Gastric Mucosa
5 important questions on Gastric Mucosa
What is the cardiac zone?
What are the glands present in the cardiac region?
What is the fundic region of the stomach?
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How is HCl secretion promoted?
2. Gastric phase: it involves the chemoreceptors and stomach distension triggering the ENS and release of ACh. The stimulation of parietal and G cells and increased pH via food bolus leads to more gastrin and HCl secretion
ACh and gastrin also stimulate mast cells and enteroendocrine cells: releases histamine which activates H2 receptors on parietal cells.
How is HCl secretion inhibited?
- G cells are inhibited, thus less gastrin, thus less HCl secretion by parietal cells
- Somatostatin secretion, thus less HCl secretion by parietal cells
- Acidification of duodenum leads to secretion of secretin, leading to exocrine pancreas and gall bladder to secrete bicarbonate into small intestine & further somatostatin and PGE2 release
- CCK secretion into bloodstream leads to release of pancreatic digestive enzymes into duodenum
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