Fundic - Parietal glands - Parietal cells
5 important questions on Fundic - Parietal glands - Parietal cells
What exactly do parietal cells do?
What do parietal cells have receptors for?
1. ACh
2. Histamine
3. Gastrin
4. CCK
Inhibitory
1. Somatostatin
2. Secretin
What is the mechanism of HCl production by parietal cells?
2. H+ and Cl- are sent to the gastric lumen
3. The OH- radical combines with CO2 to form HCO3-, HCO3- is sent to the blood
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How do we prevent H+ from entering the gastric lumen?
2. Proton pump inhibitors: inhibits entrance of H+ into gastric lumen. When [H+] rises within parietal cell, CA catalyzes its reaction in the reverse direction (produces CO2 and H2O)
Why do we not meddle with chloride pumps in parietal cells?
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