Adrenal gland - Main components of the axis
4 important questions on Adrenal gland - Main components of the axis
What are the main components of the adrenal axis?
AP: ACTH
Endocrine targets: adrenal cortex, cortisol
Non endocrine targets: many tissues
What is the effect of ACTH in the body?
- Stimulates glucocorticoid secretion (cortisol)
- Stimulates sex steroid secretion (DHEAS)
Which receptor inhibits ACTH secretion?
- Higher grades + faster learning
- Never study anything twice
- 100% sure, 100% understanding
How are corticosteroids made (steroidogenesis)?
2. cAMP stimulates StAR protein production/insertion
3. Cholesterol transported into mitochondria (via StAR protein) 4. Cholesterol moves to INNER mitochondrial membrane
5. P450scc (side-chain cleavage enzyme) acts to convert Cholesterol to Pregnenolone (P5)
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding

















