Disorders of cortisol secretion - Hyposecretion of cortisol via primary hypoadrenocorticism - Primary hypoadrenocorticism

4 important questions on Disorders of cortisol secretion - Hyposecretion of cortisol via primary hypoadrenocorticism - Primary hypoadrenocorticism

What is the cause of Addison's disease?

1. Acquired
2. Immune mediated

How do you diagnose Addison's disease?

1. Biochemistry will show electrolyte imbalances, high plasma ACTH (will confirm whether primary vs secondary)
2. ACTH stim test

How do you treat Addison's disease?

1. Restore blood volume
2. Correct electrolyte imbalances
3. Steroid preparations (aldosterone and cortisol analogs)
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What are the clinical signs of Addison's disease?

Hypotension, polyuria, emesis, diarrhea, anorexia, hypoglycemia, lethargy, hyperpigmentation

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