Adrenal gland II - Disorders of Na+ and homeostasis - Diabetes insipidus

5 important questions on Adrenal gland II - Disorders of Na+ and homeostasis - Diabetes insipidus

What is diabetes insipidus?

- Central: lack of ADH secretion from pituitary
- Nephrogenic: reduced ability of kidney to respond to ADH

What are the causes of diabetes insipidus?

- Central: Injury or inflammation to posterior pituitary or the supraoptic nucleus in the hypothalamus
- Nephrogenic: Hereditary or acquired

What are the clinical signs of diabetes insipidus?

PU/PD, very dilute urine (low USG)
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How do we diagnose diabetes insipidus?

Water deprivation test or desmopressin test

How do we treat diabetes insipidus?

Treat underlying causes

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