Lecture title - GH related disorders

5 important questions on Lecture title - GH related disorders

What leads to size extremes in dog breeds?

Dogs with two copies of one IGF-1 allele = smaller
Dogs with two copies of the same IGF-1 allele = larger
Dogs with one copy of each IGF-1 allele = intermediate

What happens in GH disorders pre-maturity?

- Underproduction (dwarfism) or reduced sensitivity (pygmy)
- Overproduction (gigantism)

What can cause pre-maturity GH disorders?

Tumors in the anterior pituitary gland
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What happens in GH disorders post maturity?

- Underproduction or reduced sensitivity: alopecia, cushing's syndrome (increased cortisol = low GH)
- Overproduction: acromegaly, with diabetes mellitus

What can cause post maturity GH disorders?

Benign pituitary tumour (adenoma)

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