Lecture title - Hormone receptors - Nuclear hormone receptors
3 important questions on Lecture title - Hormone receptors - Nuclear hormone receptors
How do nuclear hormone receptors work?
1. T4 is bound to carrier protein
2. T4 is converted to T3 that can bind to binding protein
3. Hormone uses binding protein to enter nucleus
4. Hormone binds to receptor-DNA complex
5. New mRNA is coded, and protein is synthesized
6. Hormone acts
2. T4 is converted to T3 that can bind to binding protein
3. Hormone uses binding protein to enter nucleus
4. Hormone binds to receptor-DNA complex
5. New mRNA is coded, and protein is synthesized
6. Hormone acts
Which hormone uses the nuclear hormone receptor?
Thyroxine/triiodothyronine
What is special about the nuclear hormone receptor?
It has a RXR receptor and a TR receptor, both bind to the DNA and when both are bound with ligand, they go through conformational changes that cause corepressors to be released and coactivators to bind, leading to gene expression
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