Lecture title - Hormone receptors - G-protein
3 important questions on Lecture title - Hormone receptors - G-protein
How does adenylate cyclase cAMP work as a second messenger?
1. Hormone binds to a receptor
2. Alpha subunit dissociates from G-protein complex
3. Alpha subunit activates adenylate cyclase (AC)
4. AC catalyzes the production of cAMP
5. CAMP activates protein kinase
6. Protein kinase phosphorylates other enzymes in the cell
2. Alpha subunit dissociates from G-protein complex
3. Alpha subunit activates adenylate cyclase (AC)
4. AC catalyzes the production of cAMP
5. CAMP activates protein kinase
6. Protein kinase phosphorylates other enzymes in the cell
How does phospholipase C work as a second messenger?
1. Hormone binds to a receptor
2. Alpha subunit dissociates from G-protein complex
3. Alpha subunit activates phospholipase C
4. DAG and IP3 are formed
5. IP3 binds receptors on ER
6. Stored Ca2+ diffuses into cytoplasm
2. Alpha subunit dissociates from G-protein complex
3. Alpha subunit activates phospholipase C
4. DAG and IP3 are formed
5. IP3 binds receptors on ER
6. Stored Ca2+ diffuses into cytoplasm
Which hormones use two different G-protein messenger mechanisms?
Epinephrine/norepinephrine (a1 and beta adrenergic)
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