Tutorial title - Hypothalamus - Hypothalamic control of pituitary gland

3 important questions on Tutorial title - Hypothalamus - Hypothalamic control of pituitary gland

How is the pituitary gland controlled by the hypothalamus?

Hypothalamus receives the initial signal, and the results of its production/secretion to target cells lead to feedback mechanisms that can control the activity of pituitary gland and hypothalamus.

What is an example of positive feedback regulation?

1. Suckling signals hypothalamus to produce oxytocin
2. Oxytocin is secreted in posterior pituitary
3. Oxytocin acts on mammary gland -> more milk production
4. More milk production -> more suckling -> more oxytocin produced

What is an example of negative feedback regulation?

1. Low T4 sensed by hypothalamus
2. Hypothalamus produces/secretes TRH to anterior pituitary
3. Anterior pituitary produces/secretes TSH to thyroid cells
4. Thyroid cells produce thyroxine
5. High T4 sensed by hypothalamus and anterior pituitary
6. Less TRH produced/secreted

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