Tutorial title - Hormone processing of MCRs

4 important questions on Tutorial title - Hormone processing of MCRs

Where do prohormones become processed?

Gland cells

Where is POMC produced and processed?

Anterior pituitary: Produced and cleaved into ACTH and b-lipotropin
Intermediate pituitary: Does everything AP does, then also cleaves ACTH and b-lipotropin to produce MSH, CLIP, y-LHP, and B-endorphin

What determines how POMC and its hormones are cleaved?

Prohormone convertases 1, 2, and 3
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What are melanocortin receptors?

They are G-coupled receptors (cAMP) that react to POMC derivatives in various tissues

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