Calcium - Regulation of calcium - PTH

3 important questions on Calcium - Regulation of calcium - PTH

What is the mechanism of PTH regulation of Ca2+?

1. Ca2+ sensitive receptors on parathyroid cells activate cAMP mediated release of PTH when Ca2+ signal is missing
2. PTH binds to G-protein coupled receptor (PTHR1) on target tissues (osteoclasts, kidney cells)
3. PTH is produced and released simultaneously

How do osteoclasts increase blood calcium?

Osteoclasts dissolve hydroxyapatite to allow free Ca2+ and PO4 3-, and cause bone resorption

What does PTH do in the kidney?

Regulate a calcium channel protein (TRPV5) to facilitate Ca2+ reabsorption from tubular fluid into the bloodstream. PO4 3- is inhibited from being reabsorbed to prevent buildup of calcium phosphate crystals in bone

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