Learning Goal - textbook C - T cell's antigen receptors
3 important questions on Learning Goal - textbook C - T cell's antigen receptors
How many forms of antigen receptors are there in T cells?
Two forms. Alpha/beta or Gamma/delta on their variable domain
- CD4 and CD8 are both alpha/beta
- CD4 and CD8 are both alpha/beta
What are the antigen binding receptor portions in all immune cells?
The three immunoglobulin domains are
1. Variable domains: high polymorphism
2. Constant domain: no polymorphism
3. Transmembrane domain: always within the cell membrane
1. Variable domains: high polymorphism
2. Constant domain: no polymorphism
3. Transmembrane domain: always within the cell membrane
How are T cell receptors created?
They are created in the thymus via gene rearrangements. Two chains bind to form a complete receptor (alpha/beta or gamma/delta).
CDR (complementarity determining region) between the variable and constant region bind to antigen-MHC complexes, and they are formed by junction of light V+J (in alpha/gamma chains) or heavy V+D+J (in beta/delta chains) genes.
CDR (complementarity determining region) between the variable and constant region bind to antigen-MHC complexes, and they are formed by junction of light V+J (in alpha/gamma chains) or heavy V+D+J (in beta/delta chains) genes.
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