Learning Goal - T cells
5 important questions on Learning Goal - T cells
What are the different subsets of T cells?
2. Helper cells
3. Memory cells
4. Regulatory cells
What is required for activation of T cells?
CD4+ helper T cells: CD4 as a molecule helps MHC Class II to present epitopes to helper T cell
What is the immunological synapse in T cells?
Two signals required for T cell activation
1. Formation of TCR-antigen-MHC, tri-molecular complex
2. Co-stimulation from CD80/CD86 (on APC) and CD28 (on T cell)
Third signal
3. Cytokine milieu, release of certain cytokines lead to T cells having specific phenotype (Th1 or Th2)
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How do CD4+ helper T cells aid in immune responses?
How are CD4+ T cells activated?
Signal 2: Co-stimulators (CD28 and CD80/86)
Signal 3 (not always required: Cytokines such as IL-12 driving proliferation/differentiation of T cells
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