Learning Goal - textbook C - Surface Receptors, ligands, functions
3 important questions on Learning Goal - textbook C - Surface Receptors, ligands, functions
What are some surface receptors of T cells?
Regulatory receptors
- CD25: Receptor for IL-2, which is a critical cytokine for T cell survival
- CD2: Receptor for CD58, a ligand for T cell adhesion, activation, and synapse formation
Antigen receptor complex
- CD4 or CD8: Receptors for MHC molecules
- TCR: Receptor for epitopes
- CD3: They convert extracellular antigen recognition by TCR into intracellular signals
- CD25: Receptor for IL-2, which is a critical cytokine for T cell survival
- CD2: Receptor for CD58, a ligand for T cell adhesion, activation, and synapse formation
Antigen receptor complex
- CD4 or CD8: Receptors for MHC molecules
- TCR: Receptor for epitopes
- CD3: They convert extracellular antigen recognition by TCR into intracellular signals
How does CD4 expression differ in dogs?
Unlike other species where CD4 expression is reserved for Helper T cells exclusively, macrophages and neutrophils in canines can also express CD4+.
Why is different CD4 expression in dogs clinically relevant?
It is clinically relevant for determining whether leukemia is myeloid or lymphoid.
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