Textbook C - CD4+ Helper T cells - Subsets

4 important questions on Textbook C - CD4+ Helper T cells - Subsets

What are the subsets of CD4+ helper T cells?

1. Helper 1 (Th1)
2. Helper 2 (Th2)
3. Helper 17 (Th17)
4. Regulatory (Tregs)

Characteristics of Th1 cells

- Stimulated by IL-12
- Secrete IFN-y
- Promote cytotoxic T cell mediated responses for extracellular pathogens

Characteristics of Th2 cells

- Stimulated by IL-1
- Secrete IL-4, IL-13, IL-10
- Promote antibody responses effective against extracellular pathogens
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Characteristics of Th17 cells

- Stimulated by IL-6 + TGF-B , IL-23
- Secrete IL-17
- Promote neutrophil mediated inflammation

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