Learning Goal - textbook C - Pathways for antigen processing
3 important questions on Learning Goal - textbook C - Pathways for antigen processing
What is the endogenous antigen processing pathway in T cells?
Peptides from degraded intracellular proteins (E.g. From viruses) are loaded onto MHC Class I and presented to CD8+ Cytotoxic T cells
What is the exogenous antigen processing pathway in T cells?
Peptides from endocytosed and/or degraded extracellular proteins (e.g. Bacteria) are loaded onto MHC Class II and presented to CD4+ Helper T cells
What is the cross-presentation antigen processing pathway in T cells?
1. Dendritic cell phagocytoses an infected or cancerous cell and takes up its debris
2. Peptides usually go to MHC class II
3. Normally, extracellular peptides go through MHC Class II, with helper T cells
4. Cross-presentation: some peptides get sent to MHC class I, with CD8 T cell
2. Peptides usually go to MHC class II
3. Normally, extracellular peptides go through MHC Class II, with helper T cells
4. Cross-presentation: some peptides get sent to MHC class I, with CD8 T cell
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