Lecture title - Action potential
15 important questions on Lecture title - Action potential
During polarisation the neuron is at -70mV. What does is mean and how it is created
During depolarisation what change is occurring to the mV?
During repolarisation what change is occurring to the mV?
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During hyperpolarisation what change is occurring to the mV?
What are the 3 subsequent membrane permeability changes that occur following a triggereing event?
What are the names of the 2 channels that ions pass by. Which one passively allows ions to move and which one is opened in response to a triggering event?
Voltage gate channels allow the open or close in response to changes in membrane potential
What are the 2 defining characteristics of graded potentials?
These changes occur in varying grades or degrees of magnitude or strength
Magnitude of what event influences the magnitude of the graded potential?
What is the temporarily depolarized region called?
How do graded potentials progressively diminish the farther they move from the initial active site?
What are action potentials? State 2 ways in which they different from graded potentials?
Action potentials are conducted throughout the entire membrane & the signal does not weaken or die off
What is the threshold potential? Why is it important?
If depolarization does not reach threshold potential, no action potential takes place.
What does the refractory period stop and what does it ensure? How many components does it have?
Ensures one-way propagation of action potentials.
2 components:absolute & relative refractory period
What is the difference between absolute & relative refractory periods?
Relative = a period when a second action potential can be produced but only with a stronger stimulus than before because Na+ channels are majorly closed with some ready to allow influx of Na+ and K+ channels are open as they are slow to close. Therefore the stimulus has be strong enough to get the depolarisation to threshold to begin another action potential
What 3 thing occurs to the action potential during a generalised seizure that is different to normal action potential
Increased firing rate in response to the same stimulus
Activation of T-type Ca2+ channels
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