Ligand metabolism and transport - Types of nuclear receptors
4 important questions on Ligand metabolism and transport - Types of nuclear receptors
What is the difference between nuclear receptors and Aryl hydrocarbon receptors (AhR)?
- Binding place to the DNA
- Types of dimers
AhR: specialized xenobiotic sensor, mainly regulating Phase I detoxification enzymes.
What do we specifically know about AhR?
What is an important type belonging to the NR1 family? Name 6 characteristics.
- Dimerises with RXR = Retinoid X receptor
- Regulated lipid homeostasis and energy metabolism and anti inflammatory responses
- The ligand is a fatty acid
- In toxicology it binds with PFOA (perfluorooctanoic acid)
- In pharmacology it interacts with fibrates and thiazolidinediones
- There are 3 types: alpha, gamma, Beta
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Say something about the pharmacological role of PPAR.
- Fibraten ligand voor PPAR alpha
Fibraten (drugs) activate the fatty acid oxidatie (vetverbranding).
- Verlagen de hoeveelheid triglyceriden (is iets anders dan cholesterol)
- Minder triglyceriden => minder VLDL nodig (very low density lipoprotein, belangrijk voor het transport)
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