Cell models - Kidney cells
6 important questions on Cell models - Kidney cells
Give some basic knowledge about kidney cells (2)
- Large reserve, but no functional de novo nephrogenesis.
- Glomerulus and proximal tubule most sensitive to toxins
What type of cells are in the kidney?
- Epithelial cells
- Cells within the nephron: 1. Glomerulus: podocytes (aka visceral epithelial cells), glomerular microvascular endothelial cells (GMEC) (fenestrated), glomerular mesangial cells (MC)
- 2. Cells of the Macula densa
- 3. Tubulus: proximal tubulus, thin descending loop of Henle, thin ascending loop of Henle, thick ascending loop of Henle, distal tubulus
What are important processes in the kidney? What is risky?
It is risky when drug are taken up via endocytosis => this is active transport without a transporter.
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Name two drugs that are toxic for the kidney?
- Cisplatin
- Cephaloridine
What renal cell models are available?
- Primary proximal tubule cells
- Cell lines of the proximal tubular cell line
- Widely used non-human proximal tubular cell lines
- Cell lines of human podocytes
What is one of the best proximal tubule models? Why?
Transfected cell lines with OAT1 (SLC22A6) and OAT3 (SLC22A8) transporters via lentivirus
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