Reactive oxygen species - ROS
5 important questions on Reactive oxygen species - ROS
- Names of ROS.
- Causes of ROS (intra and extra cellular)
- What are protective reactions
=> building up to anti-oxidants.
- H2O2. O2. OH.
- Intra: ETC, CYP, NADPH oxidases. Extra: macrophages
- NRF2: Nf-kB, HIF
- Antioxidant: GSH.
Where do we find the NOX family?
In non phagocyts they are important for signal transduction.
Which of the ROS, is the most radical?
Estimate: 10^9 ROS/human cell/hr
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What types of antioxidant defenses do we have?
What are catalyst for radical formation?
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