Systemic Inflammatory Responses (SIRS) - Systemic Inflammatory Responses - Spreading of Inflammation
3 important questions on Systemic Inflammatory Responses (SIRS) - Systemic Inflammatory Responses - Spreading of Inflammation
How does inflammation travel to distant organs in SIRS?
Which cytokines lead to changes in distant organs?
How do cytokines induce changes in distant organs?
- Hypothalamus via PGE2 stimulation: fever
- Brain: malaise, anorexia
- Marrow via colony stimulating factor stimulation: leukocytosis
- Liver: acute phase proteins
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