Systemic Inflammatory Responses (SIRS) - Systemic Inflammatory Responses - Spreading of Inflammation

3 important questions on Systemic Inflammatory Responses (SIRS) - Systemic Inflammatory Responses - Spreading of Inflammation

How does inflammation travel to distant organs in SIRS?

Cytokines from macrophages travel through blood and reach distant organs, causing changes in the organism, this is known as a cytokine storm.

Which cytokines lead to changes in distant organs?

IL-6, IL-1, and TNF-alpha

How do cytokines induce changes in distant organs?

IL-6, IL-1, and TNF-alpha enter circulation, become systemic and reach the organs
  • Hypothalamus via PGE2 stimulation: fever
  • Brain: malaise, anorexia
  • Marrow via colony stimulating factor stimulation: leukocytosis
  • Liver: acute phase proteins

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