Pathogenesis - Molecular principles of behaviour and progression - Cell cycle, checkpoints and DNA repair

4 important questions on Pathogenesis - Molecular principles of behaviour and progression - Cell cycle, checkpoints and DNA repair

What are the genes that stop the cell cycle?

P53 and p21

When does the cell cycle end?

After G1 and M, if there is DNA damage, TP53 and p21 induces apoptosis if repair cannot be done

What are the genes that ensure DNA repair?

BRCA1, BRCA2
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What are the consequences of DNA mismatch repair defects?

Susceptibility to polyps and cancers (e.g. Colon)

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