Pathogenesis - Molecular principles of behaviour and progression

5 important questions on Pathogenesis - Molecular principles of behaviour and progression

What are tumor suppressor genes?

Mutations that inactivate proteins involved in genomic stability and apoptosis, or proteins that counteract the effects of oncogenes

What are the receptor dynamics involved in gene expression?

1. Growth factors
2. Membrane receptors (e.g. C-KIT)
3. Signal transducers
4. Transcription factors
5. Response elements

What do mutated tyrosine kinase proteins do?

Continuously phosphorylate for downstream signaling and continuous gene transcription
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How can we stop mutated tyrosine kinase proteins?

Herceptin: Antibody that binds to the ligand binding domains of membrane receptors
Lapatinib: Counteracts signaling within cell after ligand binding

What do tumor suppressor genes do?

1. Cell cycle checkpoints
2. Initiation of apoptosis after DNA damage
3. DNA repair
4. Neutralize receptor kinase signaling
5. Regulation of cell-cell contact

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