Pathogenesis - Molecular principles of behaviour and progression
5 important questions on Pathogenesis - Molecular principles of behaviour and progression
What are tumor suppressor genes?
What are the receptor dynamics involved in gene expression?
2. Membrane receptors (e.g. C-KIT)
3. Signal transducers
4. Transcription factors
5. Response elements
What do mutated tyrosine kinase proteins do?
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How can we stop mutated tyrosine kinase proteins?
Lapatinib: Counteracts signaling within cell after ligand binding
What do tumor suppressor genes do?
2. Initiation of apoptosis after DNA damage
3. DNA repair
4. Neutralize receptor kinase signaling
5. Regulation of cell-cell contact
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