Macrophage and Lymphocyte Responses

4 important questions on Macrophage and Lymphocyte Responses

How are macrophages activated in fungal infections?

  1. Macrophage recognizes fungi
  2. Macrophage presents fungi to Th1 cell
  3. Th1 cell produces IFN-y which activates macrophages and calls in more macrophages

How do macrophages migrate during inflammation?

  1. Inflammatory mediators stimulate endothelial cells and leukocytes
  2. Rolling adhesion via selectins
  3. Firm adhesion via ICAM on endothelium and integrins on leukocytes
  4. Diapedesis
  5. Chemotaxis

What exactly do macrophages do in inflammation?

They coordinate immuno-inflammatory responses
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What are some macrophage responses to injury?

  1. Removal of necrotic debris: Tissue repair
  2. Killing of bacteria and fungi: Host defense and tissue repair
  3. Secretion of cytokines: Inflammation, host defense, tissue repair and immune responses
  4. Antigen presentation: immune responses

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