Macrophage and Lymphocyte Responses
4 important questions on Macrophage and Lymphocyte Responses
How are macrophages activated in fungal infections?
- Macrophage recognizes fungi
- Macrophage presents fungi to Th1 cell
- Th1 cell produces IFN-y which activates macrophages and calls in more macrophages
How do macrophages migrate during inflammation?
- Inflammatory mediators stimulate endothelial cells and leukocytes
- Rolling adhesion via selectins
- Firm adhesion via ICAM on endothelium and integrins on leukocytes
- Diapedesis
- Chemotaxis
What exactly do macrophages do in inflammation?
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What are some macrophage responses to injury?
- Removal of necrotic debris: Tissue repair
- Killing of bacteria and fungi: Host defense and tissue repair
- Secretion of cytokines: Inflammation, host defense, tissue repair and immune responses
- Antigen presentation: immune responses
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