Inflammation and Repair IV
4 important questions on Inflammation and Repair IV
How is DTH so many different things at the same time?
- Cell mediated immunity response: Usage of Th1 memory cells and IFN-y
- Delayed Type Hypersensitivity: in terms of clinical immunology
- Granulomatous inflammation: inflammation driven by recruitment and activation of macrophages and T lymphocytes
What are some causes of DTH/Type IV hypersensitivity reaction?
- Plants (grasses, trees, poison ivy)
- Topical medications, shampoos, disinfectants
- Textile fibres, dyes, cleansers
- Rubber, latex and plastics
- Metals
What happens in the sensitization phase of DTH?
- Antigen presentation to Th1 lymphocytes
- Antigen-specific Th1 lymphocytes proliferate and form memory T cells
- Antibody is not important in sensitization as opposed to allergy
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How long does does the sensitization phase of DTH take?
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