Inflammation and Repair IV

4 important questions on Inflammation and Repair IV

How is DTH so many different things at the same time?

  1. Cell mediated immunity response: Usage of Th1 memory cells and IFN-y
  2. Delayed Type Hypersensitivity: in terms of clinical immunology
  3. Granulomatous inflammation: inflammation driven by recruitment and activation of macrophages and T lymphocytes

What are some causes of DTH/Type IV hypersensitivity reaction?

  • Plants (grasses, trees, poison ivy)
  • Topical medications, shampoos, disinfectants
  • Textile fibres, dyes, cleansers
  • Rubber, latex and plastics
  • Metals

What happens in the sensitization phase of DTH?

  1. Antigen presentation to Th1 lymphocytes
  2. Antigen-specific Th1 lymphocytes proliferate and form memory T cells
  3. Antibody is not important in sensitization as opposed to allergy
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How long does does the sensitization phase of DTH take?

It takes multiple exposures over time

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