Acute Phase Response
4 important questions on Acute Phase Response
What is acute phase response?
What is the difference between sepsis and acute phase response?
What are the functions of acute phase proteins?
- Bacterial binding proteins: complement C3, LPS-BP, CRP, Mannan-BP
- Binds hemoglobin: haptoglobin
- Metal scavenging: ceruloplasmin
- Reduce leukocyte activation: C-reactive protein
- Cytokine scavengers: a2-macroglobulin
3. Minimize tissue damage
- Antioxidant: haptoglobin
- Neutralize leukocyte proteases: a1-antitrypsin, serine protease inhibitors
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How is SIRS and Acute Phase Response useful in diagnosis?
You can measure Acute Phase Response proteins in serum/plasma to determine severity, infection, and injury in the body.
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