Inflammation and Repair V
5 important questions on Inflammation and Repair V
What is autoimmune disease?
How is autoimmune disease induced?
What are the mechanisms of tissue damage in autoimmune diseases?
- Immune complex disease: persistent production of antibodies against self antigens (e.g. Polyarthritis, vasculitis, uveitis, glomerulonephritis)
- Antibody mediated cytotoxicity: antibodies against self antigens on cell surface (e.g. Hemolytic anemia, thrombocytopenia, myasthenia gravis, pemphigus)
Inflammation / cell killing
- T cell mediated cytotoxicity: Cytotoxic T cells against self cells (e.g. Myositis, discoid lupus, hypothyroidism, hypoadrenocorticism)
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What is the timing of the responses to injury?
- Serous or fibrinous exudate: 0-4 days, peak at 2 days
- Leukocyte infiltration: 0-12+ days, peak at 4-6 days
- 1st immune response: 5 days to weeks or months, peaking at 2+ weeks
- Repair: 6 days to weeks or months, peaking at 2+ weeks
What do various cells deal with during inflammation?
- Eosinophils: metazoan parasites e.g. Worms
- Macrophages: fungi, mycobacteria, foreign material
- Cytotoxic T cells: viruses, protozoa
- Humoral responses: edema, fibrinogen, complement, antibody, innate defense proteins
The question on the page originate from the summary of the following study material:
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- Never study anything twice again
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- 100% sure, 100% understanding
