Delayed type hypersensitivity - Elicitation Phase

3 important questions on Delayed type hypersensitivity - Elicitation Phase

What happens in the elicitation phase of DTH?

  1. Antigen presentation to antigen specific memory Th1 lymphocytes
  2. Th1 lymphocytes secrete IFN-y that activates macrophages and cytokines that induce inflammatory response

How long does the elicitation phase of DTH take?

24 to 72 hours

Why does DHT take so much longer than other hypersensitivity reactions?

Cellular processing, waiting for memory Th1 cells to be activated and waiting for memory Th1 cells to produce cytokines

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