Growth hormone: somatotropin - Regulators of GH secretion - IGF-1
6 important questions on Growth hormone: somatotropin - Regulators of GH secretion - IGF-1
What is the half life of somatomedins?
What makes IGF-1 different from GH?
- Decreases plasma glucose concentration
- Increases insulin sensitivity in tissues
- Decreases lipolysis in adipocytes
What happens with GH and IGF-1 when blood glucose is low?
2. Liver -> Glyconeolysis and gluconeogenesis to raise blood glucose and reduce glucose utilization
3. IGF-1 produced, increases somatostatin secretion, which decreases GH secretion -> increases glucose utilization, less glyconeolysis and gluconeogenesis and lowers blood glucose
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What happens with GH and IGF-1 in low blood fatty acids?
2. Adipose tissue -> lipolysis to increase fatty acid release for energy
3. IGF-1 produced, somatostatin released, which decreases GH secretion, lipolysis decreased
How do GH and IGF-1 work together in bone formation?
2. Liver -> IGF-1 produced, directly promotes bone growth and mineralization via increased chondroblast and osteocyte activity
3. IGF-1 also increases somatostatin secretion to regulate excessive growth
What are complications associated with GF use in animals?
2. Increased disease (e.g. Mastitis)
3. Adverse effects on reproduction (ovarian cysts, uterine disorders, gestation length differences)
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