Lecture title - Growth hormone: somatotropin

9 important questions on Lecture title - Growth hormone: somatotropin

What is the effect of somatotropin in the organism?

- Increased chondrocyte cell division
- Increased lipolysis in adipose tissue
- Decreased glucose utilization in most tissues
- Activation of liver's production of IGF-1,2 (somatomedins)

What are the effects of IGF-1,2 in the organism?

- Increased chondrocyte cell division
- Increased lipolysis in adipose tissue
- Deactivation of production of GH

What is growth hormone?

It is a protein hormone that binds to cytokine receptors. It is the most abundant hormone in the AP, and is synthesized, stored, and secreted by somatotrophs in the AP.
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What is the half life of growth hormone?

6-20 minutes

How does growth hormone travel around?

Can be transported as a free hormone, mostly transported bound to growth hormone binding protein (GHBP)

What is the secretion pattern of GH?

Pulsatile, in several large pulses each day of 10-30 minutes in duration

When is the largest pulse of GH secreted?

1 hour after onset of sleep

When is GH secreted the most in a lifetime?

Early in life (basal), pubertal growth spurt (highest amplitude/frequency)

What stimulates GH secretion?

1. Sleep
2. Exercise
3. Hypoglycemia
4. High dietary protein
5. Sex steroids
6. Ghrelin (hunger hormone)

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