Summary: Sleep Medicine Textbook | 9781119789017 | Claudio Basseti, et al
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1 Physiological basis of sleep
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What are the main findings and the focus of the review article titled "The neurophysiology and neurobiology of paradoxical (REM) sleep"?
- Focuses on Rapid eye movement (REM) sleep, also known as paradoxical sleep (PS), characterized by EEG activation and muscle atonia.
- Glutamatergic neurons in the sublaterodorsal tegmental nucleus (SLD) are implicated in PS-induced muscle atonia.
- Cholinergic neurons in the pontine tegmentum participate in REM sleep generation.
- Activation of SLD GABAergic neurons during wakefulness and slow-wave sleep suppresses REM sleep.
- The review discusses how various brain regions like the ventrolateral periaqueductal gray and lateral dorsal tegmentum are activated during PS by the claustrum and the supramammillary nucleus.
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