Summary: Fm2004
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1 Cellular Pathology
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1.1 Cell injury and death
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List the factors that affect cell damage
1.Duration of injury
2.Nature of injurious agent
3.Proportion and type of cells damaged
4.Ability of tissue to regenerate -
What are the three classifications of adult cells in terms of regeneration (proliferation)?
1.Labile
surfaceepithelia , lining mucosa,BM &haematopoietic cells
2.Stable (quiescent)
liver, kidney, pancreas,fibroblasts , vascular smooth muscle
3.Permanent CNS , nerve cells -
What are labile cells?
Adult cells that continuously divide/proliferate -
What are stable (quiescent) cells?
Adult cells that are able to undergo rapid division in response to stimuli -
What are permanent cells?
Non-dividing adult cells as it has no mitosis postnatally. -
What are the two possible cell responses to a stimulus?
1.Adaptation inresponse to stress
2.Cell injury inresponse toinjurious stimulus -
When does cell injury happen?
When the cell can't adapt to the stress/stimulus. -
What are the two types of cell injury?
1. Reversible injury if injury is mild, transient
2.Irreversible injury if injury is severe, progressive -
What are the two types of irreversible cell injuries?
1. Necrosis
2. Apoptosis
Both lead to cell death -
List the mechanisms of cellular adaptation
1. Hyperplasia
2. Hypertrophy
3. Atrophy
4. Metaplasia
5. Dysplasia
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Topics related to Summary: Fm2004
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Lecture title - Cell injury and death
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Lecture title - Acute inflammation
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Lecture title - Chronic inflammation
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