Summary: Fm2004

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  • 1 Cellular Pathology

  • 1.1 Cell injury and death

    This is a preview. There are 58 more flashcards available for chapter 1.1
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  • List the factors that affect cell damage 

    1. Duration of injury
    2. Nature of injurious agent
    3. Proportion and type of cells damaged
    4. Ability of tissue to regenerate
  • What are the three classifications of adult cells in terms of regeneration (proliferation)?

    1. Labile
    surface epithelia, lining mucosa, BM & haematopoietic cells
    2. Stable (quiescent)
    liver, kidney, pancreas, fibroblasts, vascular smooth muscle
    3. Permanent
    CNS, nerve cells
  • What are labile cells?

    Adult cells that continuously divide/proliferate
  • What are stable (quiescent) cells?

    Adult cells that are able to undergo rapid division in response to stimuli
  • What are permanent cells?

    Non-dividing adult cells as it has no mitosis postnatally.
  • What are the two possible cell responses to a stimulus?

    1. Adaptation in response to stress
    2. Cell injury in response to injurious stimulus
  • When does cell injury happen?

    When the cell can't adapt to the stress/stimulus.
  • What are the two types of cell injury?

    1. Reversible injury if injury is mild, transient
    2. Irreversible injury if injury is severe, progressive
  • What are the two types of irreversible cell injuries?

    1. Necrosis
    2. Apoptosis
    Both lead to cell death
  • List the mechanisms of cellular adaptation

    1. Hyperplasia
    2. Hypertrophy
    3. Atrophy
    4. Metaplasia
    5. Dysplasia

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