Role of nutrition in epigenetics
3 important questions on Role of nutrition in epigenetics
How do you interpret the bèta value for the illumina beadchip DNAm arrays and how do you calculate this?
A bèta value close to 1 means that most of CpG sites in this sample are methylated
A bèta value close to 0 means that most of CpG sites in this sample are unmethylated
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A bèta value close to 0 means that most of CpG sites in this sample are unmethylated
What is the main advantage of EWAS, epigenome-wide association study?
The main advantage of EWAS is that you don't need to have a predefined hypothesis
What is the difference between genotype arrays and epigenetic arrays?
Genotype arrays measure DNA sequence variation, specifically SNPs (single nucletiode polymorphisms. SNPs spread across the whole genome. They give representative genomde-wide covering. Use linkage disequilibrium (LD) to “tag” nearby variants. Used in GWAS
Epigenetic arrays measure dynamic DNA methylation at CpG sites. Used in EWAS
Epigenetic arrays measure dynamic DNA methylation at CpG sites. Used in EWAS
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