Gut brain axis, the gut side - intestinal architecture
6 important questions on Gut brain axis, the gut side - intestinal architecture
What is the definition of tight junctions that support the physical barrier?
What are 3 keys proteins involved in tight junctions in the epithelial cells and what are their functions?
claudin: SI - claudin 2 & 15, colon: claudin 1,3,5,8,23
occludin; has been shown to control paracellular permeability and barrier function, zonula occludens-1
JAM-A; controls ion and macromolecule permeability
Which intestinal epithelial cells form the chemical barrier of the intestine, and what are their main secreted products?
Goblet produce glycoproteins called mucins
Paneth cells produce antimicrobial peptides and secretory IgA
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Which two classes of mucins are found in the intestinal epithelium>
transmembrane mucins
gel-forming mucins
Which three classes of paneth cells are found in the intestinal epithelium?
-sIgA; blocks microbial access to epithelial receptors, entrapping them in mucus, and facilitates their removal
-lysozome; hydrolyses the polysaccharide structure of bacterial cell walls
-defensins; exhibit bactericidal activity
What are the differences in epithelial cell composition between the small intestine and colon, and relate this to the digestive function?
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